Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients,
but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings …

Abstract CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen
receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually …

Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-
tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …