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Adaptable hydrogel networks with reversible linkages for tissue engineering
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …
Spine dynamics: are they all the same?
Since Cajal's first drawings of Golgi stained neurons, generations of researchers have been
fascinated by the small protrusions, termed spines, studding many neuronal dendrites. Most …
fascinated by the small protrusions, termed spines, studding many neuronal dendrites. Most …
A highly photostable and bright green fluorescent protein
The low photostability of fluorescent proteins is a limiting factor in many applications of
fluorescence microscopy. Here we present StayGold, a green fluorescent protein (GFP) …
fluorescence microscopy. Here we present StayGold, a green fluorescent protein (GFP) …
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24. 32 and a significant overlap with schizophrenia
Molecular autism, 2017 - Springer
Background Over the past decade genome-wide association studies (GWAS) have been
applied to aid in the understanding of the biology of traits. The success of this approach is …
applied to aid in the understanding of the biology of traits. The success of this approach is …
Systemic AAV vectors for widespread and targeted gene delivery in rodents
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and
noninvasive gene transfer to the central and peripheral nervous systems. However, a …
noninvasive gene transfer to the central and peripheral nervous systems. However, a …
Dendritic spines: Revisiting the physiological role
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
PSD95: A synaptic protein implicated in schizophrenia or autism?
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease
Alzheimer's disease (AD) is a devastating disease characterized by synaptic and neuronal
loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) …
loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) …
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD
Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with
autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not …
autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not …