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Nucleic acids in modern molecular therapies: A realm of opportunities for strategic drug design
RNA vaccines have made evident to society what was already known by the scientific
community: nucleic acids will be the “drugs of the future.” By modifying the genome …
community: nucleic acids will be the “drugs of the future.” By modifying the genome …
Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics
Elucidating the structure-function relationships for therapeutic RNA mimicking
phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to the lack of …
phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to the lack of …
Calculation of energy for RNA/RNA and DNA/RNA duplex formation by molecular dynamics simulation
The development of approaches for predictive calculation of hybridization properties of
various nucleic acid (NA) derivatives is the basis for the rational design of the NA-based …
various nucleic acid (NA) derivatives is the basis for the rational design of the NA-based …
Effects of phosphoryl guanidine modification of phosphate residues on the structure and hybridization of oligodeoxyribonucleotides
Phosphoryl guanidine oligonucleotides (PGOs) are promising tools for biological research
and development of biosensors and therapeutics. We performed structural and hybridization …
and development of biosensors and therapeutics. We performed structural and hybridization …
[HTML][HTML] Diversity of Self-Assembled RNA Complexes: From Nanoarchitecture to Nanomachines
New tool development for various nucleic acid applications is an essential task in RNA
nanotechnology. Here, we determined the ability of self-limited complex formation by a pair …
nanotechnology. Here, we determined the ability of self-limited complex formation by a pair …
[HTML][HTML] Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions
Chemical modifications are applied to small interfering RNAs (siRNAs) to improve their
metabolic stability, specificity, and duration of pharmacodynamic effects. Despite …
metabolic stability, specificity, and duration of pharmacodynamic effects. Despite …
Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications
We have subjected several analogs of DNA that have been widely used as antisense
oligonucleotide (ASO) inhibitors of gene expression to comparative molecular dynamics …
oligonucleotide (ASO) inhibitors of gene expression to comparative molecular dynamics …
[HTML][HTML] Investigation of the lncRNA THOR in Mice Highlights the Importance of Noncoding RNAs in Mammalian Male Reproduction
L Zhou, J Li, J Liu, A Wang, Y Liu, H Yu, H Ouyang… - Biomedicines, 2021 - mdpi.com
THOR is a highly conserved testis-specific long noncoding RNA (lncRNA). The interaction
between THOR and the development of the male reproductive system remains unclear …
between THOR and the development of the male reproductive system remains unclear …
Change of hydration patterns upon RNA melting probed by excitations of phosphate backbone vibrations
The water hydration shell has a decisive impact on the structural and functional properties of
RNA. Changes of the RNA structure upon melting and in biochemical processes are …
RNA. Changes of the RNA structure upon melting and in biochemical processes are …