All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Cnidarians are> 600 million years old and are considered the sister group of Bilateria based
on numerous molecular phylogenetic studies. Apart from Hydra, the genomes of all major …

Injury induces systemic responses, but their functions remain elusive. Mechanisms that can
rapidly synchronize wound responses through long distances are also mostly unknown …

Pyroptosis, an inflammatory form of programmed cell death, is directly executed by
gasdermin (GSDM) depending on its N-terminal pore-forming fragment-mediated membrane …

One of the hallmarks of tissue repair is the production of reactive oxygen species (ROS),
which modulate processes such as cell proliferation. Although several attempts have been …

Regenerative potential is widespread but unevenly distributed across animals. However, our
understanding of the molecular mechanisms underlying regenerative processes is limited to …

The Notch-signalling pathway plays an important role in pattern formation in Hydra. Using
pharmacological Notch inhibitors (DAPT and SAHM1), it has been demonstrated that …

Appendage regeneration relies on the formation of blastema, a heterogeneous cellular
structure formed at the injury site. However, little is known about the early injury-activated …

Apoptosis is a regulated cell death that depends on caspases. It has mainly been studied as
a mechanism for the removal of unwanted cells. However, apoptotic cells can induce fate or …

Regeneration, the ability to restore body parts after injury, is widespread in metazoans;
however, the underlying molecular and cellular mechanisms involved in this process remain …