Detection and characterization of particles in the visible and subvisible size range is critical
in many fields of industrial research. Commercial particle analysis systems have proliferated …

History has shown that it is not as easy as one might think to differentiate between bulk
nanobubbles and nanodroplets or nanoparticles. It is generally easy to detect colloids (ie …

There are a growing number of reports in the literature of techniques to produce swarms of
long-lived nanosized bubbles. These are of interest both because their stability is …

Particles in biopharmaceutical formulations remain a hot topic in drug product development.
With new product classes emerging it is crucial to discriminate particulate active …

Nano-sized shell-stabilized gas bubbles have applications in various fields ranging from
environmental science to biomedical engineering. A resonant mass measurement (RMM) …

Peristaltic pum** can cause protein particle formation. The expected causes were
unfolding by heat in the pump head, oxidative stress by cavitation generated during roller …

In the past, analysis of micron-sized (> 1.0 μm) aggregates of therapeutic proteins has been
limited to light obscuration (LO), and appropriate quantitative methods of evaluating protein …

Interfacial adsorption is a major concern in the processing of biopharmaceutics as it not only
leads to a loss of protein, but also to particle formation. Protein particle formation during …

This study evaluated how differences in the surface properties of prefillable syringe barrels
and in-solution sampling methods affect micron aggregates and protein adsorption levels …

A methodology has been developed to measure nanoparticle mass and density, by
combining centrifugal field-flow fractionation (CeFFF; more commonly called sedimentation …