Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Mitochondria are indispensable organelles for maintaining cell energy metabolism, and also
are necessary to retain cell biological function by transmitting information as signal …

The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is
internalized into cells through LDL receptor (LDLR)-mediated endocytosis. The LDLR …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

As one of the deadliest diseases, cancer frequently resists existing therapeutics because
they do not target all cells within a progressing tumor, for example both tumor stem and …

Mitochondria are double-membrane bound organelles that not only provide energy for
intracellular metabolism, but also play a key role in the regulation of cell death …

Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They
are orchestrators of chronic obstructive pulmonary disease (COPD), with their number …

Mitochondria are multitasking organelles involved in maintaining the cell homoeostasis.
Beyond its well-established role in cellular bioenergetics, mitochondria also function as …

Insufficient PTEN-induced kinase 1 (PINK1)-mediated mitophagy and activation of caspase-
3/gasdermin E (GSDME)-dependent pyroptosis constitute the potential etiology of …

Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis
signaling. However, the underlying mechanism of BAX and BAK pore formation remains …