Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

There are different types of nutritionally mediated oxidative stress sources that trigger
inflammation. Much information indicates that high intakes of macronutrients can promote …

Although the importance of human genetic polymorphisms in therapeutic outcomes is well
established, the role of our'second genome'(the microbiome) has been largely overlooked …

Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues
such as adipose tissue and the liver. Recently, growing evidence has implicated the …

Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic
mutations together with environmental triggers can disable Paneth cell function. Here, we …

The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase …

Acetate, propionate, and butyrate are the main short-chain fatty acids (SCFAs) that arise
from the fermentation of fibers by the colonic microbiota. While many studies focus on the …

To monitor inflammation in a meaningful way, the markers used must be valid: they must
reflect the inflammatory process under study and they must be predictive of future health …

The incidence of obesity and associated metabolic diseases is increasing globally,
adversely affecting human health. Dietary fats, especially triglycerides, are an important …