Urticaria

P Kolkhir, AM Giménez-Arnau, K Kulthanan… - Nature Reviews …, 2022 - nature.com
Urticaria is an inflammatory skin disorder that affects up to 20% of the world population at
some point during their life. It presents with wheals, angioedema or both due to activation …

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

[HTML][HTML] Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria

M Maurer, W Berger, A Giménez-Arnau… - Journal of Allergy and …, 2022 - Elsevier
Background Chronic spontaneous urticaria (CSU) is inadequately controlled in many
patients and greatly affects quality of life. Remibrutinib, a highly selective, oral, novel …

The global burden of chronic urticaria for the patient and society

M Gonçalo, A Gimenéz‐Arnau… - British Journal of …, 2021 - academic.oup.com
Chronic urticaria (CU) affects about 1% of the world population of all ages, mostly young and
middle‐aged women. It usually lasts for several years (> 1 year in 25–75% of patients) and …

Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta‐analysis

J Fricke, G Ávila, T Keller, K Weller, S Lau, M Maurer… - Allergy, 2020 - Wiley Online Library
Background and objectives Urticaria is a frequent skin condition, but reliable prevalence
estimates from population studies particularly of the chronic form are scarce. The objective of …

The burden of chronic spontaneous urticaria is substantial: real‐world evidence from ASSURE‐CSU

M Maurer, M Abuzakouk, F Bérard, W Canonica… - Allergy, 2017 - Wiley Online Library
Background Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and
frustrating for patients and physicians. Real‐world evidence for the burden of CSU is limited …

Ligelizumab for chronic spontaneous urticaria

M Maurer, AM Giménez-Arnau… - … England Journal of …, 2019 - Mass Medical Soc
Background In the majority of patients with chronic spontaneous urticaria, most currently
available therapies do not result in complete symptom control. Ligelizumab is a next …

The role and relevance of mast cells in urticaria

MK Church, P Kolkhir, M Metz… - Immunological reviews, 2018 - Wiley Online Library
This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the
primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation …