Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

G Wei, K Lu, M Umar, Z Zhu, WW Lu, JR Speakman… - Bone research, 2023 - nature.com
Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Y Li, Z Cai, W Ma, L Bai, E Luo, Y Lin - Bone Research, 2024 - nature.com
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the
bone health of patients with diabetes; however, currently, there are no effective treatment …

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway

Z Gong, Y Wang, L Li, X Li, B Qiu, Y Hu - Food and Chemical Toxicology, 2023 - Elsevier
Osteoarthritis (OA) is a common degenerative joint disease, mainly presented by the
deterioration of articular cartilage. Amounts of data demonstrated this deterioration is …

Undenatured type II collagen and its role in improving osteoarthritis

R Xu, J Wu, L Zheng, M Zhao - Ageing research reviews, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease, affecting 32.5 million US adults or 242
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …

[HTML][HTML] Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis

H Yu, Z Song, J Yu, B Ren, Y Dong, Y You, Z Zhang… - Bioactive materials, 2024 - Elsevier
Osteoarthritis (OA) has emerged as a significant health concern among the elderly
population, with increasing attention paid to ferroptosis-induced OA in recent years …

MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

HH Genedy, P Humbert, B Laoulaou, B Le Moal… - Advanced Drug Delivery …, 2024 - Elsevier
Low back pain stands as a pervasive global health concern, afflicting almost 80% of adults
at some point in their lives with nearly 40% attributable to intervertebral disc degeneration …

Hypoxia and matrix metalloproteinase 13‐responsive hydrogel microspheres alleviate osteoarthritis progression in vivo

T Zhou, H **ong, SY Yao, S Wang, S Li, J Chang… - Small, 2024 - Wiley Online Library
The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …

Hydrogels for ameliorating osteoarthritis: mechanical modulation, anti‐inflammation, and regeneration

X Jiang, Y Sun, Y Lyu, H Kang, J Zhao, K Zhang… - …, 2024 - Wiley Online Library
Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for
effective suppression. Recently, significant endeavors have been explored to reveal its …