The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and
cyclin-dependent kinase 9 that regulate the elongation phase of transcription by RNA …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian
heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle …

Simple Summary CDK9, in combination with Cyclin T1, is one of the major regulators of RNA
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs
including rosiglitazone and pioglitazone. These drugs are full classical agonists for this …

The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that
controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process …

P-TEFb is a key regulator of the process controlling the processivity of RNA polymerase II
and possesses a kinase activity that can phosphorylate the carboxy-terminal domain of the …

The elongation phase of transcription by RNA polymerase II is one of the many steps during
the generation of mature mRNAs that is subject to regulation. Shortly after initiation, RNA …

Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased
understanding of disease pathobiology and genomics has led to clinical investigation of …

ABSTRACT CDK9 is a protein in constant development in cancer therapy. Herein we
present an overview of the enzyme as a target for cancer therapy. We provide data on its …