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Overview of cell death signaling pathways
Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …
The multifaceted role of TRAIL signaling in cancer and immunity
Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …
Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies
Abnormal tumour vasculature has a significant impact on tumour progression and response
to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis …
to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis …
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects
Recombinant tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is an
antitumor protein that is in clinical trials as a potential anticancer therapy but suffers from …
antitumor protein that is in clinical trials as a potential anticancer therapy but suffers from …
Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder
Schizophrenia and bipolar disorder share a number of common features, both
symptomatically and biologically. Abnormalities in the neuroimmune and the stress …
symptomatically and biologically. Abnormalities in the neuroimmune and the stress …
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death
Cells expressing oncogenic c-Myc are sensitized to TNF superfamily proteins. c-Myc also is
an important factor in determining whether a cell is sensitive to TRAIL-induced apoptosis …
an important factor in determining whether a cell is sensitive to TRAIL-induced apoptosis …
Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice
Background: An effective cancer therapeutic must selectively target tumours with minimal
systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would …
systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would …
The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway
S Wang - Oncogene, 2008 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily and has been shown to induce apoptosis in cancer cells but not normal …
TNF superfamily and has been shown to induce apoptosis in cancer cells but not normal …
Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor–related apoptosis-inducing ligand receptor activating agents
EK Rowinsky - Journal of Clinical Oncology, 2005 - ascopubs.org
Targeted induction of programmed cell death or apoptosis via the extrinsic apoptotic
pathway represents an unexploited therapeutic strategy to destroy cancer cells. The …
pathway represents an unexploited therapeutic strategy to destroy cancer cells. The …
The promise of TRAIL—potential and risks of a novel anticancer therapy
R Koschny, H Walczak, TM Ganten - Journal of molecular medicine, 2007 - Springer
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising new
anticancer biotherapeutic. As shown by many preclinical studies, TRAIL efficiently induces …
anticancer biotherapeutic. As shown by many preclinical studies, TRAIL efficiently induces …