[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …
due to their ability to augment experimental and clinical investigations. Cardiac …
Arrhythmogenic remodeling in the failing heart
Z Husti, A Varró, I Baczkó - Cells, 2021 - mdpi.com
Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …
Human cardiac fibroblast number and activation state modulate electromechanical function of hiPSC‐cardiomyocytes in engineered myocardium
Cardiac tissue engineering using hiPSC‐derived cardiomyocytes is a promising avenue for
cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation …
cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation …
Cardiac alternans: mechanisms and clinical utility in arrhythmia prevention
Sudden cardiac death (SCD) is frequently the initial manifestation of a cardiac arrhythmia,
resulting in about 350 000 deaths annually in the United States. 1 Devices such as the …
resulting in about 350 000 deaths annually in the United States. 1 Devices such as the …
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations
Sudden death after myocardial infarction (MI) is associated with electrophysiological
heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk …
heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk …
Modelling sudden cardiac death risks factors in patients with coronavirus disease of 2019: the hydroxychloroquine and azithromycin case
J Montnach, I Baro, F Charpentier, M De Waard… - EP …, 2021 - academic.oup.com
Aims Coronavirus disease of 2019 (COVID-19) has rapidly become a worldwide pandemic.
Many clinical trials have been initiated to fight the disease. Among those …
Many clinical trials have been initiated to fight the disease. Among those …
[HTML][HTML] Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans
Repolarization alternans, a periodic oscillation of long-short action potential duration, is an
important source of arrhythmogenic substrate, although the mechanisms driving it are …
important source of arrhythmogenic substrate, although the mechanisms driving it are …