The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies

S Hou, J Ma, Y Cheng, H Wang, J Sun… - Critical Reviews in Food …, 2023 - Taylor & Francis
Deoxynivalenol, also known as vomitotoxin, is produced by Fusarium, belonging to the
group B of the trichothecene family. DON is widely polluted, mainly polluting cereal crops …

Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach?

Y Liao, Z Peng, L Chen, AK Nüssler, L Liu… - Food and Chemical …, 2018 - Elsevier
Deoxynivalenol (DON, vomitoxin) is the most frequent mycotoxin in grains and grain
products. DON contamination in fodder and food is a serious threat for health, since it …

Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway …

M Tang, D Yuan, P Liao - Environmental Pollution, 2021 - Elsevier
The aim of this study was to evaluate the effect of berberine (BBR) on the intestinal health of
piglets exposed to deoxynivalenol (DON). A total of 180 weaned piglets were randomly …

Microbial biotransformation of DON: molecular basis for reduced toxicity

A Pierron, S Mimoun, LS Murate, N Loiseau, Y Lippi… - Scientific reports, 2016 - nature.com
Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to
deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON) …

Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-β-d-glucoside

A Pierron, S Mimoun, LS Murate, N Loiseau… - Archives of …, 2016 - Springer
Natural food contaminants such as mycotoxins are an important problem for human health.
Deoxynivalenol (DON) is one of the most common mycotoxins detected in cereals and …

Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

X Gao, P Mu, X Zhu, X Chen, S Tang, Y Wu, X Miao… - Toxins, 2020 - mdpi.com
Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on
humans and animals. Much effort has been made to control DON in the past, and bio …

Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: cell-cycle arrest, oxidative stress, and apoptosis

D Li, Y Ye, S Lin, L Deng, X Fan, Y Zhang… - Environmental …, 2014 - Elsevier
Deoxynivalenol (DON) is one of the most common mycotoxin contaminants of raw and
processed cereal food. Lymphoid cells and fibroblasts are specified to be the most DON …

Forthcoming challenges in mycotoxins toxicology research for safer food—a need for multi-omics approach

L Dellafiora, C Dall'Asta - Toxins, 2017 - mdpi.com
The presence of mycotoxins in food represents a severe threat for public health and welfare,
and poses relevant research challenges in the food toxicology field. Nowadays, food …

Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella)

C Huang, P Wu, WD Jiang, Y Liu, YY Zeng… - Fish & shellfish …, 2018 - Elsevier
Deoxynivalenol (DON) is one of the most common mycotoxin contaminants of animal feed
worldwide and brings significant threats to the animal production. However, studies …

Transcriptome analysis of Caco-2 cells upon the exposure of mycotoxin deoxynivalenol and its acetylated derivatives

Y He, X Yin, J Dong, Q Yang, Y Wu, Z Gong - Toxins, 2021 - mdpi.com
Deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-
ADON) are type B trichothecenes; one of the major pollutants in food and feed products …