Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …

Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death, with
limited therapeutic options available. This highlights the need for improved understanding of …

Recurrent medulloblastoma and ependymoma are universally lethal, with no approved
targeted therapies and few candidates presently under clinical evaluation. Nearly all …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior
fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further …

High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of
H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively sha** …

Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …