The biorelated degradability and clearance of siliceous nanomaterials have been
questioned worldwide, since they are crucial prerequisites for the successful translation in …

Over the years, a plethora of materials–natural and synthetic–have been engineered at a
nanoscopic level and explored for drug delivery. Nanocarriers based on such materials …

Pharmaceuticals have been developed for the treatment of a wide range of bone diseases
and disorders, but suffer from problematic delivery to the bone marrow. Neutrophils are …

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade
the immune system, cross the biological barriers of the body and localize at target tissues …

Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

Nanoparticles for biomedical applications are generally formed by bottom-up approaches
such as self-assembly, emulsification and precipitation. But these methods usually have …

Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They
have unique physicochemical properties, and have emerged as important players in current …

Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …