Kinase inhibition in autoimmunity and inflammation

AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Host-directed antiviral therapy

N Kumar, S Sharma, R Kumar, BN Tripathi… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Role of MAPK/MNK1 signaling in virus replication

R Kumar, N Khandelwal, R Thachamvally, BN Tripathi… - Virus research, 2018 - Elsevier
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Isolates from Alpinia officinarum Hance attenuate LPS‐induced inflammation in HepG2: Evidence from in silico and in vitro studies

AA Elgazar, NM Selim, NM Abdel‐Hamid… - Phytotherapy …, 2018 - Wiley Online Library
In an attempt to connect the legacy of centuries of invaluable knowledge from traditional
medicine and the current understanding to the molecular mechanism of diseases, we took …

Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targets

R Kataria, S Kaur, R Kaundal - Frontiers in Immunology, 2023 - frontiersin.org
Monkeypox virus (MPXV) is a dsDNA virus, belonging to Poxviridae family. The outbreak of
monkeypox disease in humans is critical in European and Western countries, owing to its …

Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2: in silico and molecular …

NM Selim, AA Elgazar, NM Abdel-Hamid… - Antioxidants, 2019 - mdpi.com
Hepatitis is an inflammatory condition that can develop hepatocellular carcinoma.
Traditional medicine has always been the pillar of medical practice. However, it became less …

Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum

L Shen, CZ Ai, YC Song, FW Wang… - Journal of natural …, 2019 - ACS Publications
Six new macrolides named myrothecines D–G (1–4), 16-hydroxymytoxin B (5), and 14′-
dehydrovertisporin (6), including four 10, 13-cyclotrichothecane derivatives, in addition to 12 …

[HTML][HTML] Crosstalk between the p38 and TGF‑β signaling pathways through TβRI, TβRII and Smad3 expression in plancental choriocarcinoma JEG‑3 cells

Y Tan, Q Xu, Y Li, X Mao, K Zhang - Oncology letters, 2014 - spandidos-publications.com
Choriocarcinoma is a highly aggressive tumor that develops from germ cells. Some
choriocarcinomas originate in the testes or ovaries, while others may develop in the uterus …

[HTML][HTML] Curcumin stimulates proliferation of spinal cord neural progenitor cells via a mitogen-activated protein kinase signaling pathway

S Son, KT Kim, DC Cho, HJ Kim… - Journal of Korean …, 2014 - synapse.koreamed.org
Objective The aims of our study are to evaluate the effect of curcumin on spinal cord neural
progenitor cell (SC-NPC) proliferation and to clarify the mechanisms of mitogen-activated …

[HTML][HTML] The efficacy and underlying mechanism of moxibustion in preventing cognitive impairment: a systematic review of animal studies

S Choe, M Cai, UM Jerng, JH Lee - Experimental neurobiology, 2018 - ncbi.nlm.nih.gov
Cognitive impairment is age-related and manageable only with early diagnosis and
prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive …