Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Role of MAPK/MNK1 signaling in virus replication
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …
to effectively replicate and produce new progeny virus particles. Following viral infection …
Isolates from Alpinia officinarum Hance attenuate LPS‐induced inflammation in HepG2: Evidence from in silico and in vitro studies
In an attempt to connect the legacy of centuries of invaluable knowledge from traditional
medicine and the current understanding to the molecular mechanism of diseases, we took …
medicine and the current understanding to the molecular mechanism of diseases, we took …
Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targets
Monkeypox virus (MPXV) is a dsDNA virus, belonging to Poxviridae family. The outbreak of
monkeypox disease in humans is critical in European and Western countries, owing to its …
monkeypox disease in humans is critical in European and Western countries, owing to its …
Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2: in silico and molecular …
Hepatitis is an inflammatory condition that can develop hepatocellular carcinoma.
Traditional medicine has always been the pillar of medical practice. However, it became less …
Traditional medicine has always been the pillar of medical practice. However, it became less …
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum
L Shen, CZ Ai, YC Song, FW Wang… - Journal of natural …, 2019 - ACS Publications
Six new macrolides named myrothecines D–G (1–4), 16-hydroxymytoxin B (5), and 14′-
dehydrovertisporin (6), including four 10, 13-cyclotrichothecane derivatives, in addition to 12 …
dehydrovertisporin (6), including four 10, 13-cyclotrichothecane derivatives, in addition to 12 …
[HTML][HTML] Crosstalk between the p38 and TGF‑β signaling pathways through TβRI, TβRII and Smad3 expression in plancental choriocarcinoma JEG‑3 cells
Y Tan, Q Xu, Y Li, X Mao, K Zhang - Oncology letters, 2014 - spandidos-publications.com
Choriocarcinoma is a highly aggressive tumor that develops from germ cells. Some
choriocarcinomas originate in the testes or ovaries, while others may develop in the uterus …
choriocarcinomas originate in the testes or ovaries, while others may develop in the uterus …
[HTML][HTML] Curcumin stimulates proliferation of spinal cord neural progenitor cells via a mitogen-activated protein kinase signaling pathway
Objective The aims of our study are to evaluate the effect of curcumin on spinal cord neural
progenitor cell (SC-NPC) proliferation and to clarify the mechanisms of mitogen-activated …
progenitor cell (SC-NPC) proliferation and to clarify the mechanisms of mitogen-activated …
[HTML][HTML] The efficacy and underlying mechanism of moxibustion in preventing cognitive impairment: a systematic review of animal studies
S Choe, M Cai, UM Jerng, JH Lee - Experimental neurobiology, 2018 - ncbi.nlm.nih.gov
Cognitive impairment is age-related and manageable only with early diagnosis and
prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive …
prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive …