Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical
drawback as each disease interferes with the treatment of the other. In addition to shared …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human
cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2 …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …