Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

The moderate stability of enzymes is one of the main drawbacks that hinder general
implementation of these interesting biocatalysts at industrial scale. An especially complex …

Microorganisms produce and accumulate compatible solutes aiming at protecting
themselves from environmental stresses. Among them, the wide spread in nature ectoines …

Dietary polyphenols have been associated with the reduced risk of chronic diseases such as
cancer, but the precise underlying mechanism of protection remains unclear. The aim of this …

Extremophilic microorganisms have adopted a variety of ingenious strategies for survival
under high or low temperature, extreme pressure, and drastic salt concentrations. A novel …

In the area of peptide and protein pharmaceuticals, both the physical and chemical stability
of biopharmaceuticals are critical and need to be optimised when formulating a drug …

β-Amyloid peptide (Aβ) is the major constituent of senile plaques, the key pathological
feature of Alzheimer's disease. Aβ is physiologically produced as a soluble form, but …

Hydrogen peroxide is a substrate or side-product in many enzyme-catalyzed reactions. For
example, it is a side-product of oxidases, resulting from the re-oxidation of FAD with …

Efficient development of stable formulations of protein pharmaceuticals requires an intimate
knowledge of the protein and its chemical and physical properties. In particular …

Accumulation of polyhydroxybutyrate (PHB) seems to be a common metabolic strategy
adopted by many bacteria to cope with cold environments. This work aimed at evaluating …