Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

C Pifferi, R Fuentes, A Fernández-Tejada - Nature Reviews Chemistry, 2021 - nature.com
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …

[HTML][HTML] Emerging role of natural products in cancer immunotherapy

S Dong, X Guo, F Han, Z He, Y Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer immunotherapy has become a new generation of anti-tumor treatment, but its
indications still focus on several types of tumors that are sensitive to the immune system …

Natural and synthetic saponins as vaccine adjuvants

P Wang - Vaccines, 2021 - mdpi.com
Saponin adjuvants have been extensively studied for their use in veterinary and human
vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating …

Phytochemical and Pharmacological Properties of Gymnema sylvestre: An Important Medicinal Plant

P Tiwari, BN Mishra… - BioMed research …, 2014 - Wiley Online Library
Gymnema sylvestre (Asclepiadaceae), popularly known as “gurmar” for its distinct property
as sugar destroyer, is a reputed herb in the Ayurvedic system of medicine. The …

Advances in saponin-based adjuvants

HX Sun, Y **e, YP Ye - Vaccine, 2009 - Elsevier
Saponins are natural glycosides of steroid or triterpene which exhibited many different
biological and pharmacological activities. Notably, saponins can also activate the …

Natural products to drugs: natural product derived compounds in clinical trials

MS Butler - Natural product reports, 2005 - pubs.rsc.org
Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Recent progress in adjuvant discovery for peptide-based subunit vaccines

F Azmi, AAH Ahmad Fuaad… - Human vaccines & …, 2014 - Taylor & Francis
Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are
safe, easy to produce and well defined. However, peptide antigens produce a relatively …

Birch bark research and development

PA Krasutsky - Natural product reports, 2006 - pubs.rsc.org
Covering: 1995 to 2006 This review will detail progress made in the previous decade on the
chemistry and bioactivity of birch bark extractive products. Current and future applications of …

Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity

DJ Marciani - Drug discovery today, 2003 - Elsevier
Inactivated vaccines require adjuvants to stimulate an immune response. The choice of
adjuvant or immune enhancer determines whether the immune response is effective …