Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics
Building human tissues via 3D cell printing technology has received particular attention due
to its process flexibility and versatility. This technology enables the recapitulation of unique …
to its process flexibility and versatility. This technology enables the recapitulation of unique …
[HTML][HTML] Patient-specific organoid and organ-on-a-chip: 3D cell-culture meets 3D printing and numerical simulation
The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …
architecture and function of living organs or tissues and contribute immensely to advances in …
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are
associated with cardiovascular side effects ranging from induced arrhythmias to heart …
associated with cardiovascular side effects ranging from induced arrhythmias to heart …
Identification of drug transporter genomic variants and inhibitors that protect against doxorubicin-induced cardiotoxicity
Background: Multiple pharmacogenomic studies have identified the synonymous genomic
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer
Background: Molecular targeted chemotherapies have been shown to significantly improve
the outcomes of patients who have cancer, but they often cause cardiovascular side effects …
the outcomes of patients who have cancer, but they often cause cardiovascular side effects …
Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity
Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …
market. Several chemotherapeutic compounds have been noted for their propensities to …
Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy
A Asimaki, S Kapoor, E Plovie, A Karin Arndt… - Science translational …, 2014 - science.org
Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To
elucidate the underlying mechanisms and discover potential chemical modifiers, we created …
elucidate the underlying mechanisms and discover potential chemical modifiers, we created …
iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy
Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …
children and its pathogenesis has been associated with the developmental defect of the …
Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening
AST Smith, J Macadangdang, W Leung… - Biotechnology …, 2017 - Elsevier
Improved methodologies for modeling cardiac disease phenotypes and accurately
screening the efficacy and toxicity of potential therapeutic compounds are actively being …
screening the efficacy and toxicity of potential therapeutic compounds are actively being …
Mitochondria-rich extracellular vesicles rescue patient-specific cardiomyocytes from doxorubicin injury: insights into the SENECA trial
Background Anthracycline-induced cardiomyopathy (AIC) is a significant source of morbidity
and mortality in cancer survivors. The role of mesenchymal stem cells (MSCs) in treating AIC …
and mortality in cancer survivors. The role of mesenchymal stem cells (MSCs) in treating AIC …