The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Mitogen-activated protein kinases (MAPKs), also known as extracellular signal regulated
kinases (ERKs), are found in numerous signal transduction pathways and are triggered by …

Among the aromatic heterocycle rings, pyrazole–a five-membered ring with two adjacent
nitrogen atoms in its structure has been postulated as a potent candidate in the …

A simple and efficient metal-free strategy has been developed for the synthesis of 1, 5-
disubstituted pyrazole derivatives by using 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP) …

Aminopyrazoles represent interesting structures in medicinal chemistry, and several
derivatives showed biological activity in different therapeutic areas. Previously reported 5 …

In this study, a series of derivatives of thiazolyl-pyrazole hybrid structures were designed to
search for new heterocyclic compound-based antitumor agents. The designed target …

Pyrazole and its derivatives remain popular heterocycles in drug research, design, and
development. Several drugs include the pyrazole scaffold, such as ramifenazone …

In the present study, N-(1-(2-bromobenzoyl)-4-cyano-1H-pyrazol-5-yl) halogenated
benzamides (5a-h) were prepared and evaluated for their in vitro anticancer activity against …

A visible light-promoted, efficient, green, and sustainable strategy has been adopted to
unlatch a new pathway toward the synthesis of a library of medicinally important 4, 4 …