Current scenario of pyrazole hybrids with in vivo therapeutic potential against cancers
Z Xu, Y Zhuang, Q Chen - European Journal of Medicinal Chemistry, 2023 - Elsevier
Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …
the prevalence and mortality rates of cancer remain high. The drug resistance and low …
The importance of the pyrazole scaffold in the design of protein kinases inhibitors as targeted anticancer therapies
The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
Heterocycles in breast cancer treatment: the use of pyrazole derivatives
S Ardevines, E Marqués-López… - Current Medicinal …, 2023 - ingentaconnect.com
Among the aromatic heterocycle rings, pyrazole–a five-membered ring with two adjacent
nitrogen atoms in its structure has been postulated as a potent candidate in the …
nitrogen atoms in its structure has been postulated as a potent candidate in the …
Ultrasound-assisted synthesis of 1, 5-disubstituted pyrazoles via HFIP-mediated cascade cyclization of enaminones with aryl hydrazine
A simple and efficient metal-free strategy has been developed for the synthesis of 1, 5-
disubstituted pyrazole derivatives by using 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP) …
disubstituted pyrazole derivatives by using 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP) …
Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents
Pyrazole and its derivatives remain popular heterocycles in drug research, design, and
development. Several drugs include the pyrazole scaffold, such as ramifenazone …
development. Several drugs include the pyrazole scaffold, such as ramifenazone …
Visible light-promoted green and sustainable approach for one-pot Synthesis of 4, 4'-(arylmethylene) bis (1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular …
A visible light-promoted, efficient, green, and sustainable strategy has been adopted to
unlatch a new pathway toward the synthesis of a library of medicinally important 4, 4 …
unlatch a new pathway toward the synthesis of a library of medicinally important 4, 4 …
Fluorinated and Non-Fluorinated 1,4-Diarylpyrazoles via MnO2-Mediated Mechanochemical Deacylative Oxidation of 5-Acylpyrazolines
G Utecht-Jarzyńska, A Kowalczyk, M Jasiński - Molecules, 2022 - mdpi.com
A solvent-free two-step synthesis of polyfunctionalized pyrazoles under ball-milling
mechanochemical conditions was developed. The protocol comprises (3+ 2)-cycloaddition …
mechanochemical conditions was developed. The protocol comprises (3+ 2)-cycloaddition …
Quantitative and qualitative analysis of the anti-proliferative potential of the pyrazole scaffold in the design of anticancer agents
The current work presents an objective overview of the impact of one important heterocyclic
structure, the pyrazole ring, in the development of anti-proliferative drugs. A set of 1551 …
structure, the pyrazole ring, in the development of anti-proliferative drugs. A set of 1551 …
[HTML][HTML] New Pyrazole/Pyrimidine-Based Scaffolds as Inhibitors of Heat Shock Protein 90 Endowed with Apoptotic Anti-Breast Cancer Activity
Background/Objectives: Supported by a comparative study between conventional, grinding,
and microwave techniques, a mild and versatile method based on the [1+ 3] cycloaddition of …
and microwave techniques, a mild and versatile method based on the [1+ 3] cycloaddition of …
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors
The design, synthesis, and biological activities of a new series of pyrazole derivatives are
reported. The target compounds 1a-1w were initially investigated against NCI-60 cancer cell …
reported. The target compounds 1a-1w were initially investigated against NCI-60 cancer cell …