The genetically informed neurobiology of addiction (GINA) model

R Bogdan, AS Hatoum, EC Johnson… - Nature Reviews …, 2023 - nature.com
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Brain–phenotype models fail for individuals who defy sample stereotypes

AS Greene, X Shen, S Noble, C Horien, CA Hahn… - Nature, 2022 - nature.com
Individual differences in brain functional organization track a range of traits, symptoms and
behaviours,,,,,,,,,,–. So far, work modelling linear brain–phenotype relationships has …

Machine learning with neuroimaging biomarkers: Application in the diagnosis and prediction of drug addiction

L Yang, Y Du, W Yang, J Liu - Addiction Biology, 2023 - Wiley Online Library
Drug abuse is a serious problem worldwide. Owing to intermittent intake of certain
substances and the early inconspicuous clinical symptoms, this brings huge challenges for …

[HTML][HTML] Comparison between gradients and parcellations for functional connectivity prediction of behavior

R Kong, YR Tan, N Wulan, LQR Ooi, SR Farahibozorg… - NeuroImage, 2023 - Elsevier
Resting-state functional connectivity (RSFC) is widely used to predict behavioral measures.
To predict behavioral measures, representing RSFC with parcellations and gradients are the …

A cognitive neurogenetic approach to uncovering the structure of executive functions

J Feng, L Zhang, C Chen, J Sheng, Z Ye, K Feng… - Nature …, 2022 - nature.com
One central mission of cognitive neuroscience is to understand the ontology of complex
cognitive functions. We addressed this question with a cognitive neurogenetic approach …

Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling

K Ibrahim, S Noble, G He, C Lacadie, MJ Crowley… - Molecular …, 2022 - nature.com
Disruptions in frontoparietal networks supporting emotion regulation have been long
implicated in maladaptive childhood aggression. However, the association of connectivity …

Associations among household and neighborhood socioeconomic disadvantages, resting-state frontoamygdala connectivity, and internalizing symptoms in youth

KI Ip, LM Sisk, C Horien, MI Conley… - Journal of Cognitive …, 2022 - direct.mit.edu
Exposure to socioeconomic disadvantages (SED) can have negative impacts on mental
health, yet SED are a multifaceted construct and the precise processes by which SED confer …

Distinct neural networks predict cocaine versus cannabis treatment outcomes

SD Lichenstein, R Kohler, F Ye, MN Potenza… - Molecular …, 2023 - nature.com
Abstract Treatment outcomes for individuals with substance use disorders (SUDs) are
variable and more individualized approaches may be needed. Cross-validated, machine …

Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study

KSF Damme, TG Vargas, S Walther… - Translational …, 2024 - nature.com
Adolescence is among the most vulnerable period for the emergence of serious mental
illnesses. Addressing this vulnerability has generated interest in identifying markers of risk …

Clinical promise of brain-phenotype modeling: a review

AS Greene, RT Constable - JAMA psychiatry, 2023 - jamanetwork.com
Importance Assessing the link between whole-brain activity and individual differences in
cognition and behavior has the potential to offer insights into psychiatric disorder etiology …