Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …

The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Owing to the heterogeneity of neuroendocrine neoplasms (NENs), the availability of reliable
circulating markers is critical for improving diagnostics, prognostic stratification, follow-up …

Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with
catecholamines and can function as a pro-hormone by giving rise to several bioactive …

The activation of Kupffer cells (KCs) and monocyte-derived recruited macrophages (McMΦs)
in the liver contributes to obesity-induced insulin resistance and type 2 diabetes. Mice with …

The adrenal medulla is composed predominantly of chromaffin cells producing and
secreting the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamine …

Background: Cardiovascular disease (CVD), the most common cause of death globally,
accounts for~ 30% of all deaths worldwide. Hypertension is a common contributor to …

Cellular communication relies on fusion of secretory vesicles with the plasma membrane,
following dynamic events that change the micro-and nanoscale environment of the …