Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

Several nutrition, food and dietary compounds have been suggested to be involved in the
onset and maintenance of depressive disorders and in the severity of depressive symptoms …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Introduction Bipolar disorder (BD) is a chronic mental illness impacting 1–2% of the
population worldwide and causing high rates of functional impairment. Patients with BD …

Objective Inflammation has been implicated in the risk, pathophysiology, and progression of
mood disorders and, as such, has become a target of interest in the treatment of bipolar …

Objective: Therapeutic options are limited for treatment-resistant bipolar depression (TRBD).
Insulin resistance (IR) confers increased risk for TRBD. We investigated metformin, an …

Bipolar disorder (BD) has been associated with immune changes, and yet their underlying
mechanisms are still not fully understood. Here, we review the current state of the field …

Methods For this narrative clinical overview, the MEDLINE/PubMed, Embase, Google
Scholar and ClinicalTrials. gov databases were searched from inception through June 2015 …