Applications of polymers as pharmaceutical excipients in solid oral dosage forms

N Debotton, A Dahan - Medicinal research reviews, 2017 - Wiley Online Library
Over the last few decades, polymers have been extensively used as pharmaceutical
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …

Co amorphous valsartan nifedipine system: Preparation, characterization, in vitro and in vivo evaluation

A Lodagekar, RB Chavan, MKC Mannava… - European Journal of …, 2019 - Elsevier
Co amorphous systems are supersaturated drug delivery systems which offer a basic
platform for delivery of multicomponent adducts (combination of more than one active …

[HTML][HTML] Candesartan cilexetil in vitro–in vivo correlation: predictive dissolution as a development tool

A Figueroa-Campos, B Sánchez-Dengra, V Merino… - Pharmaceutics, 2020 - mdpi.com
The main objective of this investigation was to develop an in vitro–in vivo correlation (IVIVC)
for immediate release candesartan cilexetil formulations by designing an in vitro dissolution …

Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach

D Medarević, S Cvijić, V Dobričić, M Mitrić… - European Journal of …, 2018 - Elsevier
This study aimed to improve dissolution rate of valsartan in an acidic environment and
consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected …

[HTML][HTML] Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers

B Daravath, C Naveen, SK Vemula… - Brazilian Journal of …, 2018 - SciELO Brasil
The intent of the current work is to study the effect of polyethylene glycol 8000 and
polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In …

Optimizing Nateglinide Liquisolid Compacts: Achieving Formulation Excellence Through the Quality by Design Approach

B Daravath, SK Vemula, N Chella - Journal of Pharmaceutical Innovation, 2024 - Springer
Purpose The present study aimed to improve the dissolution properties of nateglinide, an
anionic drug with poor water solubility and a high log P value, which results in decreased …

Co-delivery of novel valsartan and hydrochlorothiazide pH-responsive electrospun polymeric nanofibers for improved oral delivery

YA Haggag, M Abdel-Wahab, SS Eltokhy… - Journal of Drug Delivery …, 2024 - Elsevier
Abstract Valsartan (VAL) and Hydrochlorothiazide (HCTZ) as a fixed-dose combination are
widely used for the management of hypertension. To enhance the dissolution and oral …

Preparation and in vitro characterization of valsartan-loaded ethyl cellulose and poly (methyl methacrylate) nanoparticles

E Hajba-Horváth, E Biró, M Mirankó, A Fodor-Kardos… - RSC …, 2020 - pubs.rsc.org
Valsartan is an antihypertensive drug used primarily orally, however, due to its hydrophobic
nature it has got low bio-availability thus requiring higher dosage/frequency and causing …

Valsartan–Choline: Preparation, Characterization, and transdermal permeation

II Hamdan, D El-Sabawi, RR Ramazanov… - Journal of Molecular …, 2025 - Elsevier
Valsartan (VST) is a poorly water-soluble antihypertensive drug. The aim of this study was to
prepare, characterize, and evaluate a new salt of VST using choline (CHN) as a counter …

Improvement of bioavailability of poorly soluble racecadotril by solid dispersion with surface adsorption method: A case study

B Daravath, GP Kumari - Journal of Reports in Pharmaceutical …, 2021 - journals.lww.com
Materials and Methods: SSDs and physical mixtures (PMs) were prepared using various
ratios of hydrophilic carriers (polyethylene glycol 4000, polyethylene glycol 6000, and …