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Applications of polymers as pharmaceutical excipients in solid oral dosage forms
Over the last few decades, polymers have been extensively used as pharmaceutical
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …
excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply …
Co amorphous valsartan nifedipine system: Preparation, characterization, in vitro and in vivo evaluation
Co amorphous systems are supersaturated drug delivery systems which offer a basic
platform for delivery of multicomponent adducts (combination of more than one active …
platform for delivery of multicomponent adducts (combination of more than one active …
[HTML][HTML] Candesartan cilexetil in vitro–in vivo correlation: predictive dissolution as a development tool
A Figueroa-Campos, B Sánchez-Dengra, V Merino… - Pharmaceutics, 2020 - mdpi.com
The main objective of this investigation was to develop an in vitro–in vivo correlation (IVIVC)
for immediate release candesartan cilexetil formulations by designing an in vitro dissolution …
for immediate release candesartan cilexetil formulations by designing an in vitro dissolution …
Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach
D Medarević, S Cvijić, V Dobričić, M Mitrić… - European Journal of …, 2018 - Elsevier
This study aimed to improve dissolution rate of valsartan in an acidic environment and
consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected …
consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected …
[HTML][HTML] Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers
The intent of the current work is to study the effect of polyethylene glycol 8000 and
polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In …
polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In …
Optimizing Nateglinide Liquisolid Compacts: Achieving Formulation Excellence Through the Quality by Design Approach
Purpose The present study aimed to improve the dissolution properties of nateglinide, an
anionic drug with poor water solubility and a high log P value, which results in decreased …
anionic drug with poor water solubility and a high log P value, which results in decreased …
Co-delivery of novel valsartan and hydrochlorothiazide pH-responsive electrospun polymeric nanofibers for improved oral delivery
Abstract Valsartan (VAL) and Hydrochlorothiazide (HCTZ) as a fixed-dose combination are
widely used for the management of hypertension. To enhance the dissolution and oral …
widely used for the management of hypertension. To enhance the dissolution and oral …
Preparation and in vitro characterization of valsartan-loaded ethyl cellulose and poly (methyl methacrylate) nanoparticles
E Hajba-Horváth, E Biró, M Mirankó, A Fodor-Kardos… - RSC …, 2020 - pubs.rsc.org
Valsartan is an antihypertensive drug used primarily orally, however, due to its hydrophobic
nature it has got low bio-availability thus requiring higher dosage/frequency and causing …
nature it has got low bio-availability thus requiring higher dosage/frequency and causing …
Valsartan–Choline: Preparation, Characterization, and transdermal permeation
Valsartan (VST) is a poorly water-soluble antihypertensive drug. The aim of this study was to
prepare, characterize, and evaluate a new salt of VST using choline (CHN) as a counter …
prepare, characterize, and evaluate a new salt of VST using choline (CHN) as a counter …
Improvement of bioavailability of poorly soluble racecadotril by solid dispersion with surface adsorption method: A case study
B Daravath, GP Kumari - Journal of Reports in Pharmaceutical …, 2021 - journals.lww.com
Materials and Methods: SSDs and physical mixtures (PMs) were prepared using various
ratios of hydrophilic carriers (polyethylene glycol 4000, polyethylene glycol 6000, and …
ratios of hydrophilic carriers (polyethylene glycol 4000, polyethylene glycol 6000, and …