Background Rutin as a natural flavonoid compound has revealed an extensive range of
therapeutic potentials. Purpose The current paper is focused on the numerous studies on …

The surface chemistry, pendent functional entities, and ease in tunability of various materials
play a central role in properly coordinating with enzymes for immobilization purposes. Due …

Mitochondria are critical multifunctional organelles in cells that generate power, produce
reactive oxygen species, and regulate cell survival. Mitochondria that are dysfunctional are …

Designing a therapeutic modality that will reach a certain organ, tissue, or cell type is crucial
for both the therapeutic efficiency and to limit off-target adverse effects. Nanoparticles …

The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …

The use of magnetic nanoparticles (MNPs) in biomedical applications has been wildly opted
due to their unique properties. Here, we designed MNPs loaded with erlotinib (ERL/SPION …

Cancer is considered the most aggressive malignancy to humans, and definitely the major
cause of death worldwide. Despite the different and heterogenous presentation of the …

Breast cancer is one of the most life-threatening malignancies with high mortality among
women. Chemotherapy, radiotherapy, surgical operation, and combination therapy are …

Cancer immunotherapy, a major breakthrough in cancer treatment, has been successfully
applied to treat a number of tumors. However, given the presence of factors in the tumor …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most recalcitrant cancers due to its
late diagnosis, poor therapeutic response, and highly heterogeneous microenvironment …