Structural, molecular, and functional insights into Schlafen proteins
Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …
sequence homology. However, each SLFN is functionally divergent and differentially …
The schlafen family of proteins and their regulation by interferons
E Mavrommatis, EN Fish… - Journal of Interferon & …, 2013 - liebertpub.com
The Schlafen (SLFN) family of proteins includes several mouse and human members. There
is emerging evidence that members of this family of proteins are involved in important …
is emerging evidence that members of this family of proteins are involved in important …
Programmed cell death ligand 1 (PD-L1) signaling regulates macrophage proliferation and activation
Tumor-associated macrophages (TAMs) express programmed cell death ligand 1 (PD-L1)
and contribute to the immune-suppressive tumor microenvironment. Although the role of the …
and contribute to the immune-suppressive tumor microenvironment. Although the role of the …
Map** macrophage polarization over the myocardial infarction time continuum
AJ Mouton, KY DeLeon-Pennell… - Basic research in …, 2018 - Springer
In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …
scar formation. We hypothesized that macrophages undergo polarization state changes over …
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated
with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the …
with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the …
G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling
LG Schuettpelz, JN Borgerding, MJ Christopher… - Leukemia, 2014 - nature.com
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells
(HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and …
(HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and …
[HTML][HTML] Hedgehog signaling links chronic inflammation to gastric cancer precursor lesions
JL Merchant, L Ding - Cellular and molecular gastroenterology and …, 2017 - Elsevier
Since its initial discovery in Drosophila, Hedgehog (HH) signaling has long been associated
with foregut development. The mammalian genome expresses 3 HH ligands, with sonic …
with foregut development. The mammalian genome expresses 3 HH ligands, with sonic …
SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects
SJ Fletcher, B Johnson, GC Lowe… - The Journal of …, 2015 - Am Soc Clin Investig
Inherited thrombocytopenias are a group of disorders that are characterized by a low platelet
count and are sometimes associated with excessive bleeding that ranges from mild to …
count and are sometimes associated with excessive bleeding that ranges from mild to …
The Schlafen family: complex roles in different cell types and virus replication
F Liu, P Zhou, Q Wang, M Zhang… - Cell biology …, 2018 - Wiley Online Library
The Schlafen (slfn) gene family members express broadly, but the research has mainly
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
[HTML][HTML] Toll-like Receptor 9 pathway mediates Schlafen+-MDSC polarization during Helicobacter-induced gastric metaplasias
Background & Aims A subset of myeloid-derived suppressor cells (MDSCs) that express
murine Schlafen4 (SLFN4) or its human ortholog SLFN12L polarize in the Helicobacter …
murine Schlafen4 (SLFN4) or its human ortholog SLFN12L polarize in the Helicobacter …