The array of whiskers on the snout provides rodents with tactile sensory information relating
to the size, shape and texture of objects in their immediate environment. Rodents can use …

Neuroscience research has exploded, with more than fifty thousand neuroscientists applying
increasingly advanced methods. A mountain of new facts and mechanisms has emerged …

Perceptual decisions involve distributed cortical activity. Does information flow sequentially
from one cortical area to another, or do networks of interconnected areas contribute at the …

The mouse is an increasingly prominent model for the analysis of mammalian neuronal
circuits. Neural circuits ultimately have to be probed during behaviors that engage the …

Neural computation involves diverse types of GABAergic inhibitory interneurons that are
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …

Comprehensive measurement of neural activity remains challenging due to the large
numbers of neurons in each brain area. We used volumetric two-photon imaging in mice …

Our understanding of the neural basis of somatosensation is based largely on studies of the
whisker system of mice and rats and the hands of macaque monkeys. Results across these …

For many of our senses, the role of the cerebral cortex in detecting stimuli is
controversial,,,,,,,,,,,,,,,–. Here we examine the effects of both acute and chronic inactivation of …

Active sensation requires the convergence of external stimuli with representations of body
movements. We used mouse behavior, electrophysiology and optogenetics to dissect the …

During many natural behaviors the relevant sensory stimuli and motor outputs are difficult to
quantify. Furthermore, the high dimensionality of the space of possible stimuli and …