Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Develo** an …

In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Malaria is a major public health burden throughout the world. Resistance to the antimalarial
drugs has increased the mortality and morbidity rate that is achieved so far through the …

Background The candidate vaccines against malaria are poorly immunogenic and thus have
been ineffective in preventing infection. We developed a vaccine based on the …

Background To further increase the efficacy of malaria vaccine RTS, S/AS02A, we tested the
RTS, S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals) …

Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …

In recent malaria sporozoite vaccine trials in humans and mice, antibodies to the sporozoite
coat protein have given only modest protection against sporozoite challenge. In contrast …

Summary Background RTS, S/AS02 is a pre-erythrocytic malaria vaccine based on the
circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a …