Impact of oxidative stress on exercising skeletal muscle
It is well established that muscle contractions during exercise lead to elevated levels of
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy
DG Allen, NP Whitehead… - Physiological …, 2016 - journals.physiology.org
Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
Reactive oxygen species: beyond their reactive behavior
Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …
Disruption of this fragile equilibrium is often associated with health degradation and …
[HTML][HTML] New functions of mitochondria associated membranes in cellular signaling
In all eukaryotic cells, the endoplasmic reticulum (ER) and the mitochondria establish a tight
interplay, which is structurally and functionally modulated through a proteinaceous tether …
interplay, which is structurally and functionally modulated through a proteinaceous tether …
Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components
Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …
Oxidative stress and beta-cell dysfunction
G Drews, P Krippeit-Drews, M Düfer - Pflügers Archiv-European Journal of …, 2010 - Springer
Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …
Taurine: the appeal of a safe amino acid for skeletal muscle disorders
A De Luca, S Pierno, DC Camerino - Journal of translational medicine, 2015 - Springer
Taurine is a natural amino acid present as free form in many mammalian tissues and in
particular in skeletal muscle. Taurine exerts many physiological functions, including …
particular in skeletal muscle. Taurine exerts many physiological functions, including …
A Self‐Reinforcing Nanoplatform for Highly Effective Synergistic Targeted Combinatary Calcium‐Overload and Photodynamic Therapy of Cancer
While calcium‐overload‐mediated therapy (COMT) is a promising but largely untapped
therapeutic strategy, combinatory therapy greatly boosts treatment outcomes with integrated …
therapeutic strategy, combinatory therapy greatly boosts treatment outcomes with integrated …
Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle – pivotal roles in Ca2+ and reactive oxygen species signaling
Mitochondria are strategically and dynamically positioned in the cell to spatially coordinate
ATP production with energy needs and to allow the local exchange of material with other …
ATP production with energy needs and to allow the local exchange of material with other …
MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin/nNOS pathway
In Duchenne muscular dystrophy (DMD) the absence of dystrophin at the sarcolemma
delocalizes and downregulates nitric oxide synthase (nNOS); this alters S-nitrosylation of …
delocalizes and downregulates nitric oxide synthase (nNOS); this alters S-nitrosylation of …