The preparation of compounds labelled with deuterium or tritium has become an essential
tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to …

Hydrogen isotope exchange (HIE) has become one of the most studied methods to prepare
deuterated molecules, with the primary focus recently on metal-catalyzed C–H activation …

Hydroxylated (hetero) arenes are valued in many industries as both key constituents of end
products and diversifiable synthetic building blocks. Accordingly, the development of …

Deuteration has emerged as a significant method for investigating kinetic isotope effects in
chemical reactions. In recent years, research on deuteration has revealed that this reaction …

We herein present a method for the synthesis of ortho-deuterated aryl nitrile using Mn (CO)
5Br as catalyst with CH3OD as deuteratium source, where the structure of aryl imidates is …

The K2CO3/18-crown-6-catalyzed H/D exchange of heretoarenes in high atom% deuterium
incorporation is disclosed. The use of a weak base as a catalyst leads to excellent site …

Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of
deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical …

AIBN is a convenient electrophilic cyanation reagent for transforming ArLi into ArCN under
mild conditions. The addition/fragmentation cascade is controlled by Li··· N chelation in …

Silver-catalyzed deuteration of nitroaromatics has been achieved using D2O as the
deuterium source. Distinct from the well-established directing group-guided hydrogen …

Herein, we first report a γ-selective deuteration reaction of pyridines via H/D exchange
without the need for preinstalled directing groups and transformable functional groups. The …