Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …

WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor
suppressor gene, has over the years become recognized for its role in a much wider range …

WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in
developmental, epileptic, and ataxic phenotypes of varying severity based on the level of …

In this study, loss of expression of the fragile site-encoded Wwox protein was found to
contribute to radiation and cisplatin resistance of cells, responses that could be associated …

Introduction Zinc finger-like protein that regulates apoptosis (Zfra) is a naturally occurring 31-
amino-acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block …

Induction of DNA damage response (DDR) to ensure accurate duplication of genetic
information is crucial for maintaining genome integrity during DNA replication. Cellular …

Liver cancer is one of the most lethal malignancies with very poor prognosis once
diagnosed. The most common form of liver cancer is hepatocellular carcinoma (HCC). The …

Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play
an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX …

Individual differences in sleep duration have been reported, and genetic components of
sleep duration have been identified showing various heritability. To identify genetic variants …

It has become clear from multiple studies that WWOX (WW domain-containing
oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in …