Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …

Therapeutic proteins have a propensity for aggregation during manufacturing, ship**, and
storage. The presence of aggregates in protein drug products can induce adverse immune …

Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …

The role in human health of therapeutic proteins in general, and monoclonal antibodies
(mAbs) in particular, has been significant and is continuously evolving. A considerable …

In this review, we attempt to give a concise overview of recent progress made in mechanistic
understanding of protein aggregation, particulate formation and protein solution rheology …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …

A host of diverse stress techniques was applied to a monoclonal antibody (IgG 2) to yield
protein particles with varying attributes and morphologies. Aggregated solutions were …

Background: Aggregated biotherapeutics have the potential to induce an immune response.
Results: Aggregates can enhance innate and adaptive immune responses of PBMC …