Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes | Chemical Reviews ACS
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Conspectus This Account is aimed at highlighting the recent developments in the N-
heterocyclic carbene (NHC)-catalyzed generation of α, β-unsaturated acylazolium …

N‐Heterocyclic carbene (NHC) organocatalysis has been developed as an important
approach in modern organic synthesis. Versatile activation modes within NHC …

First reported less than a decade ago, the α, β-unsaturated acyl azolium has emerged as a
central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis …

Catalytic reactions promoted by N-heterocyclic carbenes (NHCs) have exploded in
popularity since 2004 when several reports described new fundamental reactions that …

The principle of vinylogy states that the electronic effects of a functional group in a molecule
are possibly transmitted to a distal position through interposed conjugated multiple bonds …

The enantioselective synthesis of pyrazolone‐fused spirocyclohexadienones was
demonstrated by the reaction of α, β‐unsaturated aldehydes with α‐arylidene pyrazolinones …

Significance: Chi and co-workers report a formal LUMO-lowering activation of α, β-
unsaturated esters 1 with N-heterocyclic carbene (NHC) precursors A, B, or C as catalysts …

The catalytic cyclocondensation of in situ activated α, β‐unsaturated carboxylic acids was
developed. N‐heterocyclic carbenes efficiently catalyzed the generation of α, β‐unsaturated …

The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …