Child and adolescent obesity

NB Lister, LA Baur, JF Felix, AJ Hill, C Marcus… - Nature Reviews …, 2023 - nature.com
The prevalence of child and adolescent obesity has plateaued at high levels in most high-
income countries and is increasing in many low-income and middle-income countries …

Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity

W Ghusn, A De la Rosa, D Sacoto… - JAMA Network …, 2022 - jamanetwork.com
Importance No retrospective cohort study has assessed the effectiveness of semaglutide at
doses used in randomized clinical trials to treat obesity (ie, 1.7 and 2.4 mg). Objective To …

[HTML][HTML] Diets and drugs for weight loss and health in obesity–An update

J Aaseth, S Ellefsen, U Alehagen, TM Sundfør… - Biomedicine & …, 2021 - Elsevier
Numerous combinations of diets and pharmacological agents, including lifestyle changes,
have been launched to treat obesity. There are still ambiguities regarding the efficacies of …

[HTML][HTML] Hypertension related to obesity: pathogenesis, characteristics and factors for control

P El Meouchy, M Wahoud, S Allam, R Chedid… - International journal of …, 2022 - mdpi.com
The World Health Organization (WHO) refers to obesity as abnormal or excessive fat
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …

Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective …

NL Syn, DE Cummings, LZ Wang, DJ Lin, JJ Zhao… - The Lancet, 2021 - thelancet.com
Background Metabolic–bariatric surgery delivers substantial weight loss and can induce
remission or improvement of obesity-related risks and complications. However, more robust …

Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions

SS Garg, K Kushwaha, R Dubey, J Gupta - Diabetes research and clinical …, 2023 - Elsevier
Obesity, a metabolic disorder, is becoming a worldwide epidemic that predominantly
increases the risk for various diseases including metabolic inflammation, insulin resistance …

Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity

DP Fisher, E Johnson, S Haneuse, D Arterburn… - Jama, 2018 - jamanetwork.com
Importance Macrovascular disease is a leading cause of morbidity and mortality for patients
with type 2 diabetes, and medical management, including lifestyle changes, may not be …