X-Chromosome–Linked miRNAs Regulate Sex Differences in Cardiac Physiology
JI Emerson, W Shi, J Paredes-Larios… - Circulation …, 2025 - ahajournals.org
BACKGROUND: Males and females exhibit distinct anatomic and functional characteristics
of the heart, predisposing them to specific disease states. METHODS: We identified …
of the heart, predisposing them to specific disease states. METHODS: We identified …
Feeding behavior modifies the circadian variation in RR and QT intervals by distinct mechanisms in mice
M Ono, DE Burgess, SR Johnson… - American Journal …, 2024 - journals.physiology.org
Rhythmic feeding behavior is critical for regulating phase and amplitude in the≈ 24-h
variation of heart rate (RR intervals), ventricular repolarization (QT intervals), and core body …
variation of heart rate (RR intervals), ventricular repolarization (QT intervals), and core body …
[HTML][HTML] Calcium handling abnormalities increase arrhythmia susceptibility in DMSXL myotonic dystrophy type 1 mice
Background Myotonic dystrophy type 1 (DM1) is a multiorgan disorder with significant
cardiac involvement. ECG abnormalities, including arrhythmias, occur in 80% of DM1 …
cardiac involvement. ECG abnormalities, including arrhythmias, occur in 80% of DM1 …
Sex-Specific Response to A1BG Loss Results in Female Dilated Cardiomyopathy
Background Cardiac disease often manifests differently in terms of frequency and pathology
between men and women. However, the mechanisms underlying these differences are not …
between men and women. However, the mechanisms underlying these differences are not …
Measuring arterial stiffness at different scales: a new toolbox for safety pharmacology
CD Wesley - 2025 - repository.uantwerpen.be
Safety pharmacology is a key discipline in drug development, designed to evaluate potential
adverse pharmacodynamic effects of new chemical entities on vital physiological functions …
adverse pharmacodynamic effects of new chemical entities on vital physiological functions …