TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major
pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from …

Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …

Stringent control of the NF-κB and type I interferon signaling pathways is critical to effective
host immune responses, yet the molecular mechanisms that negatively regulate these …

Glioma is the most common malignant tumor in the central nervous system. Altered long
noncoding RNAs (lncRNAs) are playing regulatory roles in physiological and pathogenic …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Inflammatory signaling underlies many diseases, from arthritis to cancer. Our understanding
of inflammation has thus far been limited to the world of proteins, because we are only just …

Tight regulation of NF-κB signaling is essential for innate and adaptive immune responses,
yet the molecular mechanisms responsible for its negative regulation are not completely …

IκB kinase β (IKKβ) plays a crucial role in biological processes, including immune response,
stress response, and tumor development by mediating the activation of various signaling …