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Epigenetics in eating disorders: a systematic review
Eating disorders are complex heritable conditions influenced by both genetic and
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …
Epigenetic research in neuropsychiatric disorders: the “tissue issue”
Abstract Purpose of Review Evidence has linked neuropsychiatric disorders with epigenetic
marks as either a biomarker of disease, biomarker of exposure, or mechanism of disease …
marks as either a biomarker of disease, biomarker of exposure, or mechanism of disease …
A genomic atlas of systemic interindividual epigenetic variation in humans
Background DNA methylation is thought to be an important determinant of human
phenotypic variation, but its inherent cell type specificity has impeded progress on this …
phenotypic variation, but its inherent cell type specificity has impeded progress on this …
A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates
Background Cytosine DNA methylation is a heritable epigenetic mark present in most
eukaryotic groups. While the patterns and functions of DNA methylation have been …
eukaryotic groups. While the patterns and functions of DNA methylation have been …
Crosstalk of genetic variants, allele-specific DNA methylation, and environmental factors for complex disease risk
Over the past decades, genome-wide association studies (GWAS) have identified thousands
of phenotype-associated DNA sequence variants for potential explanations of inter …
of phenotype-associated DNA sequence variants for potential explanations of inter …
Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia
The epigenetic changes of RELN that are involved in the development of dopaminergic
neurons may fit the developmental theory of schizophrenia. However, evidence regarding …
neurons may fit the developmental theory of schizophrenia. However, evidence regarding …
[HTML][HTML] Genetic and epigenetic biomarkers linking Alzheimer's disease and age-related macular degeneration
Alzheimer's disease (AD) represents a prominent neurodegenerative disorder (NDD),
accounting for the majority of dementia cases worldwide. In addition to memory deficits …
accounting for the majority of dementia cases worldwide. In addition to memory deficits …
Profiling the immune epigenome across global cattle breeds
Background Understanding the variation between well and poorly adapted cattle breeds to
local environments and pathogens is essential for breeding cattle with improved climate and …
local environments and pathogens is essential for breeding cattle with improved climate and …
Metastable epialleles in humans
First identified in isogenic mice, metastable epialleles (MEs) are loci where the extent of
DNA methylation (DNAm) is variable between individuals but correlates across tissues …
DNA methylation (DNAm) is variable between individuals but correlates across tissues …
How to make DNA methylome wide association studies more powerful
Genome-wide association studies had a troublesome adolescence, while researchers
increased statistical power, in part by increasing subject numbers. Interrogating the …
increased statistical power, in part by increasing subject numbers. Interrogating the …