Disease burden of hepatocellular carcinoma: a global perspective

M Sayiner, P Golabi, ZM Younossi - Digestive diseases and sciences, 2019 - Springer
Liver cancer is one of the leading causes of cancer-related mortality around the world.
Hepatocellular carcinoma (HCC) is the primary cancer of the liver, accounting for the …

The changing epidemiology of liver diseases in the Asia–Pacific region

MCS Wong, JLW Huang, J George, J Huang… - Nature reviews …, 2019 - nature.com
This Review presents current epidemiological trends of the most common liver diseases in
Asia–Pacific countries. Hepatitis B virus (HBV) remains the primary cause of cirrhosis; …

Pembrolizumab versus placebo as second-line therapy in patients from Asia with advanced hepatocellular carcinoma: a randomized, double-blind, phase III trial

S Qin, Z Chen, W Fang, Z Ren, R Xu… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE We evaluated the efficacy and safety of pembrolizumab in patients from Asia with
previously treated advanced hepatocellular carcinoma (HCC). METHODS In a double-blind …

Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses

B Zuo, Y Zhang, K Zhao, L Wu, H Qi, R Yang… - Journal of hematology & …, 2022 - Springer
Background Personalized immunotherapy utilizing cancer vaccines tailored to the tumors of
individual patients holds promise for tumors with high genetic heterogeneity, potentially …

Etiology of hepatocellular carcinoma: special focus on fatty liver disease

D Suresh, AN Srinivas, DP Kumar - Frontiers in Oncology, 2020 - frontiersin.org
Hepatocellular Carcinoma (HCC) is a highly aggressive cancer with mortality running
parallel to its incidence and has limited therapeutic options. Chronic liver inflammation and …

Recent advances in hepatocellular carcinoma therapy

R Dutta, RI Mahato - Pharmacology & therapeutics, 2017 - Elsevier
Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest
cancers due to its complexities, reoccurrence after surgical resection, metastasis and …

Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula zuo** pill in suppressing hepatocellular …

W Guo, J Huang, N Wang, HY Tan, F Cheung… - Frontiers in …, 2019 - frontiersin.org
Hepatocellular carcinoma (HCC) is a kind of complicated disease with an increasing
incidence all over the world. A classic Chinese medicine formula, Zuo** pill (ZJP), was …

Pathogenicity and virulence of Hepatitis B virus

YC Chuang, KN Tsai, JHJ Ou - Virulence, 2022 - Taylor & Francis
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …

[HTML][HTML] Overview of Asian clinical practice guidelines for the management of hepatocellular carcinoma: An Asian perspective comparison

Y Cho, BH Kim, JW Park - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is highly prevalent and the third most common cause of
cancer-related death in Asia. In contrast to the West, the main etiology of HCC in many Asian …

Molecular mechanisms behind safranal's toxicity to HepG2 cells from dual omics

DR Nelson, AA Hrout, AS Alzahmi, A Chaiboonchoe… - Antioxidants, 2022 - mdpi.com
The spice saffron (Crocus sativus) has anticancer activity in several human tissues, but the
molecular mechanisms underlying its potential therapeutic effects are poorly understood …