Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Prions, the infectious agents of transmissible spongiform encephalopathies (TSEs), have
defied full characterization for decades. The dogma has been that prions lack nucleic acids …

Individuals infected with prions succumb to brain damage, and prion infections continue to
be inexorably lethal. However, many crucial steps in prion pathogenesis occur in lymphatic …

The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Although its involvement in prion replication and neurotoxicity during transmissible
spongiform encephalopathies is undisputed, the physiological role of the cellular prion …

The key pathogenic event in prion disease involves misfolding and aggregation of the
cellular prion protein (PrP). Beyond this fundamental observation, the mechanism by which …

Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Prions are infectious proteins and over the past few decades, some prions have become
renowned for their causative role in several neurodegenerative diseases in animals and …

Prion protein (PrP) plays a key role in the pathogenesis of prion diseases. However, the
normal function of the protein remains unclear. The cellular isoform (PrPC) is expressed …

Prion protein (PrP C) is implicated in the pathogenesis of prion disorders, but its normal
function is unclear. We demonstrate that PrP C is a ferrireductase (FR), and its absence …