Therapeutic nanoparticles and their targeted delivery applications

AA Yetisgin, S Cetinel, M Zuvin, A Kosar, O Kutlu - Molecules, 2020 - mdpi.com
Nanotechnology offers many advantages in various fields of science. In this regard,
nanoparticles are the essential building blocks of nanotechnology. Recent advances in …

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

Recent applications of PLGA based nanostructures in drug delivery

M Mir, N Ahmed, A ur Rehman - Colloids and Surfaces B: Biointerfaces, 2017 - Elsevier
Over the years, issues associated with non-biodegradable polymers have paved the way for
biodegradable polymers in the domain of pharmaceutical and biomedical sciences. Poly …

Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

X Lu, L Miao, W Gao, Z Chen, KJ McHugh… - Science translational …, 2020 - science.org
Activation of the stimulator of interferon gene (STING) pathway within the tumor
microenvironment has been shown to generate a strong antitumor response. Although local …

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics

D Ding, Q Zhu - Materials Science and Engineering: C, 2018 - Elsevier
Recent advancements in biopharmaceutical industry have facilitated the development of
novel bioactive macromolecular therapeutics. One of the challenges towards the clinical use …

Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?

A Oryan, A Kamali, A Moshiri… - Cells Tissues …, 2017 - karger.com
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Role of angiogenesis in bone repair

U Saran, SG Piperni, S Chatterjee - Archives of biochemistry and …, 2014 - Elsevier
Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

The potential use of mesenchymal stem cells and their derived exosomes for orthopedic diseases treatment

K Malekpour, A Hazrati, M Zahar, A Markov… - Stem cell reviews and …, 2022 - Springer
Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints.
These disorders are very painful and severely limit patients' mobility and are more common …

Vascularized bone tissue engineering: approaches for potential improvement

LH Nguyen, N Annabi, M Nikkhah, H Bae… - … Engineering Part B …, 2012 - liebertpub.com
Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Nanomedicine and drug delivery systems in cancer and regenerative medicine

E Garbayo, S Pascual‐Gil… - Wiley …, 2020 - Wiley Online Library
Nanomedicine and drug delivery technologies play a prominent role in modern medicine,
facilitating better treatments than conventional drugs. Nanomedicine is being increasingly …