Drug resistance and treatment failure in leishmaniasis: A 21st century challenge
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …
needed on a global basis because treatment failure is an increasing problem. Drug …
[HTML][HTML] Leishmania infections: Molecular targets and diagnosis
Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …
methods and the discovery of suitable biomarkers. We propose firstly an update …
Microreact: visualizing and sharing data for genomic epidemiology and phylogeography
Visualization is frequently used to aid our interpretation of complex datasets. Within
microbial genomics, visualizing the relationships between multiple genomes as a tree …
microbial genomics, visualizing the relationships between multiple genomes as a tree …
Trypanosomatids are much more than just trypanosomes: clues from the expanded family tree
Trypanosomes and leishmanias are widely known parasites of humans. However, they are
just two out of several phylogenetic lineages that constitute the family Trypanosomatidae …
just two out of several phylogenetic lineages that constitute the family Trypanosomatidae …
Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
Protozoan persister-like cells and drug treatment failure
Antimicrobial treatment failure threatens our ability to control infections. In addition to
antimicrobial resistance, treatment failures are increasingly understood to derive from cells …
antimicrobial resistance, treatment failures are increasingly understood to derive from cells …
Global genome diversity of the Leishmania donovani complex
Protozoan parasites of the Leishmania donovani complex–L. donovani and L. infantum–
cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome …
cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome …
Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
Melarsoprol resistance in African trypanosomiasis
Arsenicals were introduced as monotherapies for the treatment of human African
trypanosomiasis, or slee** sickness, over 100 years ago. Toxicity has always been an …
trypanosomiasis, or slee** sickness, over 100 years ago. Toxicity has always been an …
[HTML][HTML] Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance
MCN Laffitte, P Leprohon, B Papadopoulou… - …, 2016 - ncbi.nlm.nih.gov
Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …