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Multi-target design strategies for the improved treatment of Alzheimer's disease
P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …
poses a substantial burden on human health, economy, and society throughout the world …
Current status and future prospects of nanoscale metal–organic frameworks in bioimaging
The importance of the early-stage diagnosis and in situ monitoring of lesion regions and
transportation of bioactive molecules has a pivotal effect on successful treatment, reducing …
transportation of bioactive molecules has a pivotal effect on successful treatment, reducing …
Recent studies focusing on the development of fluorescence probes for zinc ion
F Wang, K Wang, Q Kong, J Wang, D **, B Gu… - Coordination Chemistry …, 2021 - Elsevier
Zinc is of great importance to humans and other biological systems. For example, too high or
low levels of zinc (II) ions (Zn 2+) can result in various human disease states, and poor …
low levels of zinc (II) ions (Zn 2+) can result in various human disease states, and poor …
A near infrared fluorescent probe for detection and bioimaging of zinc ions and hypochlorous acid
L Yan, H Yang, J Li, C Zhou, L Li, X Wu, C Lei - Analytica Chimica Acta, 2022 - Elsevier
It is of great significance to monitor zinc ions (Zn 2+) and hypochlorous acid (HClO)
conveniently in disease diagnosis and environmental protection. Herein, we successfully …
conveniently in disease diagnosis and environmental protection. Herein, we successfully …
Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review
H Khanam, A Ali, M Asif - European journal of medicinal chemistry, 2016 - Elsevier
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt–Jacob,
Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the …
Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the …
MALDI mass spectrometry imaging: A cutting‐edge tool for fundamental and clinical histopathology
R Longuespée, R Casadonte… - PROTEOMICS …, 2016 - Wiley Online Library
Histopathological diagnoses have been done in the last century based on hematoxylin and
eosin staining. These methods were complemented by histochemistry, electron microscopy …
eosin staining. These methods were complemented by histochemistry, electron microscopy …
[HTML][HTML] Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
X-ray fluorescence imaging of metals and metalloids in biological systems
Metals and metalloids play fundamental roles in many physiological processes in biological
systems, but imbalance of these elements in the body may cause many diseases, such as …
systems, but imbalance of these elements in the body may cause many diseases, such as …
Antioxidative and neuroprotective effects of curcumin in an Alzheimer's disease rat model co-treated with intracerebroventricular streptozotocin and subcutaneous D …
HC Huang, BW Zheng, Y Guo, J Zhao… - Journal of …, 2016 - journals.sagepub.com
Epidemiological data imply links between the increasing incidences of Alzheimer's disease
(AD) and type 2 diabetes mellitus. In this study, an AD rat model was established by …
(AD) and type 2 diabetes mellitus. In this study, an AD rat model was established by …
[HTML][HTML] Health effects of metals in particulate matter
There is increased evidence of the association of air pollution and deleterious health effects.
Particulate matter (PM) has obtained more attention, especially the small size components …
Particulate matter (PM) has obtained more attention, especially the small size components …