Multi-target design strategies for the improved treatment of Alzheimer's disease

P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

Current status and future prospects of nanoscale metal–organic frameworks in bioimaging

M Nazari, AS Saljooghi, M Ramezani… - Journal of Materials …, 2022 - pubs.rsc.org
The importance of the early-stage diagnosis and in situ monitoring of lesion regions and
transportation of bioactive molecules has a pivotal effect on successful treatment, reducing …

Recent studies focusing on the development of fluorescence probes for zinc ion

F Wang, K Wang, Q Kong, J Wang, D **, B Gu… - Coordination Chemistry …, 2021 - Elsevier
Zinc is of great importance to humans and other biological systems. For example, too high or
low levels of zinc (II) ions (Zn 2+) can result in various human disease states, and poor …

A near infrared fluorescent probe for detection and bioimaging of zinc ions and hypochlorous acid

L Yan, H Yang, J Li, C Zhou, L Li, X Wu, C Lei - Analytica Chimica Acta, 2022 - Elsevier
It is of great significance to monitor zinc ions (Zn 2+) and hypochlorous acid (HClO)
conveniently in disease diagnosis and environmental protection. Herein, we successfully …

Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review

H Khanam, A Ali, M Asif - European journal of medicinal chemistry, 2016 - Elsevier
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt–Jacob,
Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the …

MALDI mass spectrometry imaging: A cutting‐edge tool for fundamental and clinical histopathology

R Longuespée, R Casadonte… - PROTEOMICS …, 2016 - Wiley Online Library
Histopathological diagnoses have been done in the last century based on hematoxylin and
eosin staining. These methods were complemented by histochemistry, electron microscopy …

[HTML][HTML] Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy

A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

X-ray fluorescence imaging of metals and metalloids in biological systems

R Zhang, L Li, Y Sultanbawa… - American journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Metals and metalloids play fundamental roles in many physiological processes in biological
systems, but imbalance of these elements in the body may cause many diseases, such as …

Antioxidative and neuroprotective effects of curcumin in an Alzheimer's disease rat model co-treated with intracerebroventricular streptozotocin and subcutaneous D …

HC Huang, BW Zheng, Y Guo, J Zhao… - Journal of …, 2016 - journals.sagepub.com
Epidemiological data imply links between the increasing incidences of Alzheimer's disease
(AD) and type 2 diabetes mellitus. In this study, an AD rat model was established by …

[HTML][HTML] Health effects of metals in particulate matter

TI Fortoul, V Rodriguez-Lara… - Current air quality …, 2015 - intechopen.com
There is increased evidence of the association of air pollution and deleterious health effects.
Particulate matter (PM) has obtained more attention, especially the small size components …