The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

This review examines the current understanding of how the lymphatic vessel network can
optimize lymph flow in response to various mechanical forces. Lymphatics are organized as …

Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of
people worldwide. Due to its critical role in the process of inflammation, a dysfunctional …

The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the closed, high-pressure and circular blood vascular …

Resolution of edema remains a significant clinical challenge. Conditions such as traumatic
shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to …

Background Lymphatic dysfunction has been linked to inflammation since the 1930s.
Lymphatic function in the gut and mesentery is grossly underexplored in models of …

Background Microvascular leakage of plasma proteins is a hallmark of inflammation that
leads to tissue dysfunction. There are no current therapeutic strategies to reduce …

The contractile activity of muscle cells lining the walls of collecting lymphatics is responsible
for generating and regulating flow within the lymphatic system. Activation of PKC signaling …

Recently, it has been reported that a σ-receptor antagonist could reduce inflammation-
induced edema. Lymphatic vessels play an essential role in removing excess interstitial …

Background Goreisan is a traditional herbal formulation with diuretic properties tested as a
clinical therapeutic to alleviate lymphedema in Japan. The present study aimed to determine …