NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …
animal cells is a widespread area of research, yet little is known about the reactivity and …
[HTML][HTML] Metallodrug binding to serum albumin: Lessons from biophysical and structural studies
A Merlino - Coordination Chemistry Reviews, 2023 - Elsevier
Human serum albumin (HSA) plays a major role in the transport of metallodrugs, affecting
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …
Dinuclear Organoruthenium Complex for Mitochondria-Targeted Near-Infrared Imaging and Anticancer Therapy to Overcome Platinum Resistance
J Wang, Y Zhang, Y Li, E Li, W Ye, J Pan - Inorganic Chemistry, 2022 - ACS Publications
New mononuclear and dinuclear Ru (II) coordination compounds with the 2, 7-
bisbenzoimidazolyl-naphthyridine ligand have been synthesized and characterized by UV …
bisbenzoimidazolyl-naphthyridine ligand have been synthesized and characterized by UV …
Heterodinuclear Ru–Pt complexes bridged with 2, 3-bis (pyridyl) pyrazinyl ligands: studies on kinetics, deoxyribonucleic acid/bovine serum albumin binding and …
R Bellam, D Jaganyi, RS Robinson - ACS omega, 2022 - ACS Publications
Di-and poly-homo/heteronuclear complexes have great potential as anticancer drugs. Here,
we report their reactivity, deoxyribonucleic acid (DNA)/bovine serum albumin (BSA) binding …
we report their reactivity, deoxyribonucleic acid (DNA)/bovine serum albumin (BSA) binding …
Controversial role of transferrin in the transport of ruthenium anticancer drugs
Ruthenium complexes are at the forefront of developments in metal-based anticancer drugs,
but many questions remain open regarding their reactivity in biological media, including the …
but many questions remain open regarding their reactivity in biological media, including the …
Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
Mass spectrometry imaging is being increasingly used in metal-based anticancer drug
development to study elemental and/or molecular drug distributions in different biological …
development to study elemental and/or molecular drug distributions in different biological …
Synthesis and antiproliferative activity of benzimidazole-based, trinuclear neutral cyclometallated and cationic, N^ N-chelated ruthenium (ii) complexes
A series of 2-phenyl and 2-pyridyl tris-benzimidazole ligands was reacted with the [Ru (p-
cymene) Cl2] 2 dimer to yield the corresponding neutral cyclometallated and cationic …
cymene) Cl2] 2 dimer to yield the corresponding neutral cyclometallated and cationic …
Advances in element speciation analysis of biomedical samples using synchrotron-based techniques
Synchrotron-radiation X-ray absorption spectroscopy (XAS) is a direct method for speciation
analysis with atomic resolution, providing information about the local chemical environment …
analysis with atomic resolution, providing information about the local chemical environment …
Dinuclear RuII(bipy)2 Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation
OA Lenis-Rojas, C Roma-Rodrigues… - Inorganic …, 2017 - ACS Publications
Ruthenium-based drugs exhibit interesting properties as potential anticancer
pharmaceuticals. We herein present the synthesis and characterization of a new family of …
pharmaceuticals. We herein present the synthesis and characterization of a new family of …