As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Colorectal cancer is a leading cause of cancer related mortality in the Western world. In
recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment …

A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated
transcription factors and opened chromatins to initiate transcription. However, it remains …

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a putative tumor
suppressor in which expression is significantly reduced in human cancer cell lines and …

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1), a XIAP-binding protein, is a
tumor suppressor gene. XAF1 was silent or expressed lowly in most human malignant …

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that functions as a
growth suppressor in normal epithelial cells and early stage tumors, but acts as a tumor …

Abstract XIAP-associated factor 1 (Xaf1) binds XIAP and re-localizes it to the nucleus, thus
inhibiting XIAP activity and enhancing apoptosis [1]. Xaf1 expression is reduced or absent in …

One function ascribed to apoptosis is the suicidal destruction of potentially harmful cells,
such as cancerous cells. Hence, their growth depends on evasion of apoptosis, which is …

Background & Aims: X-linked inhibitor of apoptosis protein-associated factor 1 (XAF1) is a
candidate tumor suppressor located at the chromosome 17p13 region, but the molecular …

Tumor necrosis factor-α (TNF-α) and Fas ligand induce apoptosis by interacting with their
corresponding membrane-bound death receptors and activating caspases. Since both …