The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
The sequence of the human genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
The thioredoxin antioxidant system
J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
Versatile and open software for comparing large genomes
The newest version of MUMmer easily handles comparisons of large eukaryotic genomes at
varying evolutionary distances, as demonstrated by applications to multiple genomes. Two …
varying evolutionary distances, as demonstrated by applications to multiple genomes. Two …
Molecular basis of bacterial outer membrane permeability revisited
H Nikaido - Microbiology and molecular biology reviews, 2003 - Am Soc Microbiol
Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …
the outer membrane. Although outer membrane components often play important roles in …
A genomic perspective on protein families
RL Tatusov, EV Koonin, DJ Lipman - Science, 1997 - science.org
In order to extract the maximum amount of information from the rapidly accumulating
genome sequences, all conserved genes need to be classified according to their …
genome sequences, all conserved genes need to be classified according to their …
Helicobacter pylori Infection
H. pylori is one of the most common bacterial infections in human beings, and its discovery
20 years ago altered the diagnosis and treatment of gastroduodenal disease. This review …
20 years ago altered the diagnosis and treatment of gastroduodenal disease. This review …
Microbial heavy-metal resistance
DH Nies - Applied microbiology and biotechnology, 1999 - Springer
We are just beginning to understand the metabolism of heavy metals and to use their
metabolic functions in biotechnology, although heavy metals comprise the major part of the …
metabolic functions in biotechnology, although heavy metals comprise the major part of the …
[HTML][HTML] The complete genome sequence of the Gram-positive bacterium Bacillus subtilis
FJ Kunst, N Ogasawara, I Moszer, AM Albertini… - Nature, 1997 - nature.com
Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome
of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding …
of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding …
Pathogenesis of Helicobacter pylori Infection
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the
most successful human pathogens, as over half of the world's population is colonized with …
most successful human pathogens, as over half of the world's population is colonized with …