Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Overcoming the translational crisis of contemporary psychiatry–converging phenomenological and spatiotemporal psychopathology

G Northoff, J Daub, D Hirjak - Molecular Psychiatry, 2023 - nature.com
Despite all neurobiological/neurocomputational progress in psychiatric research, recent
authors speak about a 'crisis of contemporary psychiatry'. Some argue that we do not yet …

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

KH Preller, JB Burt, JL Ji, CH Schleifer, BD Adkinson… - Elife, 2018 - elifesciences.org
Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-
HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific …

All roads lead to the default-mode network—global source of DMN abnormalities in major depressive disorder

A Scalabrini, B Vai, S Poletti, S Damiani… - …, 2020 - nature.com
Major depressive disorder (MDD) is a psychiatric disorder characterized by abnormal resting
state functional connectivity (rsFC) in various neural networks and especially in default …

Bring the noise: reconceptualizing spontaneous neural activity

LQ Uddin - Trends in Cognitive Sciences, 2020 - cell.com
Definitions of what constitutes the 'signal of interest'in neuroscience can be controversial,
due in part to continuously evolving notions regarding the significance of spontaneous …

Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders

B Conio, M Martino, P Magioncalda, A Escelsior… - Molecular …, 2020 - nature.com
Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …

Using temporal ICA to selectively remove global noise while preserving global signal in functional MRI data

MF Glasser, TS Coalson, JD Bijsterbosch, SJ Harrison… - Neuroimage, 2018 - Elsevier
Temporal fluctuations in functional Magnetic Resonance Imaging (fMRI) have been
profitably used to study brain activity and connectivity for over two decades. Unfortunately …

Psilocybin induces time-dependent changes in global functional connectivity

KH Preller, P Duerler, JB Burt, JL Ji, B Adkinson… - Biological …, 2020 - Elsevier
Background The use of psilocybin in scientific and experimental clinical contexts has
triggered renewed interest in the mechanism of action of psychedelics. However, its time …

All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders

G Northoff, D Hirjak, RC Wolf, P Magioncalda… - Molecular …, 2021 - nature.com
Psychomotor abnormalities have been abundantly observed in psychiatric disorders like
major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCH). Although …

[HTML][HTML] Spatiotemporal neuroscience–what is it and why we need it

G Northoff, S Wainio-Theberge, K Evers - Physics of life reviews, 2020 - Elsevier
The excellent commentaries to our target paper hint upon three main issues,(i)
spatiotemporal neuroscience;(ii) neuro-mental relationship; and (iii) mind, brain, and world …