Chalcone derivatives: Role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Paraptosis: A non-classical paradigm of cell death for cancer therapy

C Xu, Y Lin, M Huang, X Zhang, P Wang… - Acta Pharmacologica …, 2024 - nature.com
Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential
strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic …

Advances in autophagy modulation of natural products in cervical cancer

T Tao, P Zhang, Z Zeng, M Wang - Journal of ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Natural products play a critical role in drug development
and is emerging as a potential source of biologically active metabolites for therapeutic …

Exploring paraptosis as a therapeutic approach in cancer treatment

LC Chang, SK Chiang, SE Chen, MC Hung - Journal of Biomedical …, 2024 - Springer
A variety of cell death pathways play critical roles in the onset and progression of multiple
diseases. Paraptosis, a unique form of programmed cell death, has gained significant …

CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells

SK Chiang, WC Chang, SE Chen, LC Chang - Cell & Bioscience, 2024 - Springer
Background Paraptosis is a programmed cell death characterized by cytoplasmic
vacuolation, which has been explored as an alternative method for cancer treatment and is …

A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis

L Ma, X Xuan, M Fan, Y Zhang, G Yuan, G Huang, Z Liu - Apoptosis, 2022 - Springer
Chemotherapy represents one of the main conventional therapies for breast cancer.
However, tumor cells develop mechanisms to evade chemotherapeutic-induced apoptosis …

Integrative chemoproteomics reveals anticancer mechanisms of silver (i) targeting the proteasome regulatory complex

X Shao, F **ng, Y Zhang, CN Lok, CM Che - Chemical Science, 2024 - pubs.rsc.org
Silver compounds have favorable properties as promising anticancer drug candidates, such
as low side effects, anti-inflammatory properties, and high potential to overcome drug …

Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death

X Wen, H Ma - Cancer Science, 2025 - Wiley Online Library
Cytoplasmic vacuolization is a cellular morphological alteration characterized by the
presence of substantial vacuole‐like structures originating from various cellular organelles …

Facile synthesis of corticiolic acid—a bioactive pharmacophore from natural sources

SK Deevi, B Anilkumar, PG Pinto, P Ramani… - RSC …, 2024 - pubs.rsc.org
Fungal strains have inspired us to find the untapped sources of secondary metabolites.
Corticiolic acid (CA, 2, 4-dihydroxy-6-pentadecylbenzoic acid; from fungus, Hapalopilus …

[PDF][PDF] Chalcone derivatives: Role in anticancer therapy. Biomolecules. 2021; 11: 894

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - 2021 - researchgate.net
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …